Refractory complex regional pain syndrome resulting in amputation with dermatosis neglecta: A case report
Hatice Ceylan
, Kubra Unlu, Gizem Kilinç Kamaci, Nurdan Korkmaz, Yasin Demir, Koray Aydemir
Department of Physical Medicine and Rehabilitation, Health Sciences University, Ankara Gaziler Physical Therapy and Rehabilitation Training and Research Hospital, Ankara, Türkiye
Keywords: Amputation, analgesia, complex regional pain syndrome, dermatosis neglecta, hyperkeratosis, neglect-like symptoms, nerve injury.
Abstract
Complex regional pain syndrome (CRPS) is a painful condition which may develop after trauma. A 28-year-old male patient with severe hand pain that persisted despite long-term and multidisciplinary treatment was admitted to our clinic. The patient had severe pain and cutaneous findings. His extreme cutaneous findings were diagnosed as dermatosis neglecta (DN) associated with CRPS. To the best of our knowledge, this is the first reported case of DN occurring in association with CRPS. This case report highlights that extreme skin changes may occur in the advanced stages of complex regional pain syndrome, and when this stage is reached, treatment becomes challenging and can be controlled with irreversible treatments such as amputation.
Cite this article as: Ceylan H, Unlu K, Kilinç Kamaci G, Korkmaz N, Demir Y, Aydemir K. Refractory complex regional pain syndrome resulting in amputation with dermatosis neglecta: A case report. Agri 2026;38(4):292-297. doi: 10.5606/agri.2026.12.