Adipose derived stromal vascular fraction cells therapy in hemophilic arthropathy: A case report
Derya Güner1
, Can Eyigör2
1Department of Algology, Health Sciences University, İzmir Tepecik Training and Research Hospital, İzmir, Türkiye
2Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, İzmir, Türkiye
Keywords: Hemophilic arthrosis, intraarticular injection, mesenchymal stem cells, stromal vascular fraction.
Abstract
Stromal vascular fraction (SVF) is a heterogeneous collection of cells obtained from adipose tissue through lipoaspiration and is an alter-native intraarticular treatment option, especially in osteoarthritis (OA). The anti-inflammatory and extracellular tissue repair-stimulating properties of SVF increase its effectiveness in regeneration and repair mechanisms. One of the most common symptoms of hemophilia A and B is hemophilic arthropathy (HA). If HA is not adequately managed initially, patients may require major surgery, including total joint arthroplasty. In a 34-year-old male patient who was treated with intraarticular adipose-derived SVF with the diagnosis of hemophilia B and right grade 4 hemophilic knee arthrosis, clinical and radiological scores showed significant improvement in the 3rd month, 6th month, and 1st year controls after the procedure. Intraarticular adipose-derived SVF treatment should be kept in mind as an effective treatment option with minimal invasiveness and few side effects in HA that does not respond to conservative treatments.