Effect of Lornoxicam on Postoperative Analgesia After Myomectomy
İpek Erdoğan1, Türkay Çakan1, Ayşe Özcan1, Esra Türkyılmaz1, Bülent Baltacı1, Bayazit Dikmen2
1Department Of Anesthesiology And Reanimation, Ankara Training And Research Hospital, Ministry Of Health, Ankara, Turkey
2* Department Of Anesthesiology And Reanimation, Ankara Numune Training And Research Hospital, Ministry Of Health, Ankara, Turkey
Keywords: Postoperative analgesia, nonsteroidal-antiinflammatory drugs, lornoxicam, myomectomy
Abstract
BACKGROUND: In this prospective, randomized study, we evaluate the postoperative analgesic effect of lornoxicam after myomectomy operations. MATERIAL-METHOD: Forty ASA I-II patients scheduled for myomectomy operation were enrolled to this study. Patients were randomly divided into two groups and epidural block was performed with 0,75 % ropivacaine. After the operation, morphine Patient Controlled Epidural Analgesia (PCEA) combined with placebo (saline 2 ml iv) and morphine PCEA combined with lornoxicam 8 mg iv were administered to patients in Group I and Group II, respectively. Pain was assessed at the 0,1st, 2nd, 4th, 6th, 8th, 12th and 24th hours postoperatively. Chi-square and student’s t tests were used for statistical analysis.
RESULTS: VAS( Visual Analog Scale) scores were higher in Group I than Group II at 2nd, 4th, 6th and 24th hours. Total morphine consumption was 10.45± 4.03 in Group I and 4.25 ± 1.74 in Group II. CONCLUSION: Single dose iv lornoxicam is a safe and an effective treatment option of post-myomectomy pain as it produces effective analgesia, reduces morphine consumption and does not increase the side effects.