Convulsion due to application of low dose meperidine: a case report

Abstract

Meperidine is an opiod analgesic used in a variety of clinical situations. The active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause irritability, hyperreflexia, tremor, myoclonus and seizures. Previously identified risk factors fort he development of meperidine–related seizures include renal failure, high meperidine dosages and co-adminestration of hepatic enzyme inducing medications or phenothiazines which decreases seizure treshold. Patients with normal renal function rarely manifest seizure activity when given meperidine. Here we report a 10 years old boy with femur fraction whom had normal renal function and we used low dose meperidine due to post operative pains.