Evidence-based medicine: botulinum toxin A in migraine and tension-type headache

H. Göbel; A., Heinze; K. Heinze-kuhn; W. H. Jost

H. Göbel^¹, A., Heinze^¹, K. Heinze-kuhn^¹, W. H. Jost^²

¹Kiel Pain Clinic, Kiel, Germany
²Department Of Nurology And Clinical Neurophysiology, Deutsche Clinic Für Diagnostik, Wesbadn, Germany

Keywords: Botulinum toxin, headache, migraine, tension-type, cluster

Abstract

The therapeutic effect of botulinum toxin in headache was observed coincidentally. The rationale for this new indication initially met with a great deal of scepticism, because the toxin’s mechanism of action, cholinergic chemodenervation, does not fit the pathophysiological concept of migraine and other forms of headache. Meanwhile a fair number of studies have been published which indicate efficacy for botulinum toxin and recommend its use for the treatment of tension headache and migraine. According to the evidence-based medicine criteria, grade I evidence has been demonstrated. In addition the use of botulinum toxin for cluster-headache and secondary headache is discussed. Further large scale studies will be regarded to demonstrate the long-term efficacy..

BibTex	`@article{ agri105, author = {H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost}, title = {Evidence-based medicine: botulinum toxin A in migraine and tension-type headache}, journal = {Agri}, year = {2002}, volume = {14}, number = {1}, pages = {38-42}, publisher = {The Turkish Society of Algology} }`
RIS	`TY - JOUR AU - H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost PY - 2002 TI - Evidence-based medicine: botulinum toxin A in migraine and tension-type headache SP - 38 EP - 42 JO - The Journal of the Turkish Society of Algology J2 - Agri VL - 14 IS - 1 PB - ER -`
EndNote	`%0 Journal Article %A H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost %T Evidence-based medicine: botulinum toxin A in migraine and tension-type headache %J The Journal of the Turkish Society of Algology %D 2002 %V 14 %N 1 %P 38-42`
APA	H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost (2002). Evidence-based medicine: botulinum toxin A in migraine and tension-type headache. The Journal of the Turkish Society of Algology, 14(1), 38-42.
MLA	H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost. "Evidence-based medicine: botulinum toxin A in migraine and tension-type headache" The Journal of the Turkish Society of Algology, vol. 14, no. 1, 2002, pp. 38-42.
Chicago	H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost. "Evidence-based medicine: botulinum toxin A in migraine and tension-type headache" The Journal of the Turkish Society of Algology 14, no. 1 (2002): 38-42.
AMA	H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost. Evidence-based medicine: botulinum toxin A in migraine and tension-type headache. Agri. 2002; 14(1): 38-42.
Vancouver	H. Göbel, A., Heinze, K. Heinze-kuhn, W. H. Jost. Evidence-based medicine: botulinum toxin A in migraine and tension-type headache. Agri. 2002; 14(1): 38-42.

Evidence-based medicine: botulinum toxin A in migraine and tension-type headache

Abstract

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