Effect of ondansetron in lower extremity bone surgery on morphine and tramadol consumption using patient controlled analgesia
Zeynep Çubukçu, Hayri Özbek, Yasemin Güneş, Murat Gündüz, Dilek Özcengiz, Geylan Işık
Cukurova University Faculty Of Medicine Department Of Anesthesiology, Adana, Turkey
Keywords: Morphine HCl, Ondansetron, Patient Controlled Analgesia, Postoperative Analgesia, Tramadol HCl.
Abstract
In this study, we aimed to assess the effect of administration of ondansetron in patient undergoing morphine and tramadol using patient controlled analgesia procedure for postoperative analgesia on analgesic consumption.
After approval by the ethic committee, 120 patient planned to receive lower extremity surgery with ASA status I or II were included in the study. Patients were randomly divided into 4 groups following the induction. Group I received tramadol as PCA with an infusion of 0.3 mg/kg following a loading dose of 1.5 mg/kg administered 1 hour before the end of surgery. Group II received ondansetron 0.1 mg/kg following induction of anesthesia, additionally. Group III received morphine as PCA with an infusion following a loading dose of 0.15 mg/kg administered 30 minutes before the end of surgery. Group IV received ondansetron 0.1 mg/kg following induction of anesthesia, additionally.
Pain scores(VAS), nausea, vomitting and sedation scores, analgesic consumptions and adverse effects were recorded at 5th, 15th, 30th, 45th minutes and 4th, 8th, 12th and 24th hours postoperatively.
Postoperative VAS, nausea, vomitting and sedation scores were similar among the groups. The analgesic consumption was found significantly higher at 4th, 8th, 12th and 24th hours in group II. No statistical significant difference was found in analgesic consumption between group III and IV at all times.
We concluded that, ondansetron, when administered as antiemetic prophylaxia in patients receiving tramadol and morphine as PCA, did not effect morphine consumption whereas did increased tramadol consumption.