Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi

Suna Akın Takmaz; Çetin Kaymak; Başak Şare Pehlivan; Bayazit Dikmen

Suna Akın Takmaz^¹, Çetin Kaymak^¹, Başak Şare Pehlivan^¹, Bayazit Dikmen^²

¹Ankara Training And Research Hospital, Department Of Anesthesiology And Reanimation, Ankara, Turkey
²Ankara Numune Training And Research Hospital, Department Of Second Anesthesiology And Reanimation, Ankara, Turkey

Keywords: Gabapentin, postoperative analgesia, open cholecystectomy

Abstract

In this study, the effects of preoperative 900 and 1200mg single dose of gabapentin on postoperative pain relief and tramadol consumption in elective open cholecystectomies were investigated. Fourtyfive ASAI-II patients were randomly divided into three groups. GroupI was control group and patients in groupII and III received 900mg or 1200mg gabapentin 1 hour before the operations respectively. All patients received intravenous tramadol at the end of surgery via a PCA device. Pain scores were evaluated at the recovery room(0),1,2,3,4,6,8,12 and 24h postoperatively at rest and movement, using a 10cm VAS. In the recovery room, VAS scores at rest were three times less (1,4±0.6 versus 4,9±1.0 and 4.4±1.1), and VAS scores at movement were two times less (3.4±1.0 versus 6.8±1.8 ve 6.1±1.6) in groupIII when compared to groupI and II respectively. Mean loading doses were significantly lower in groupIII (28.3±8.7) than groupI (66.6±20.4) and II (61.6±20.8). VAS scores at rest during the postoperative first 6h and at movement during the postoperative first 8h were significantly lower in groupIII than groupI and II. Total tramadol consumption was lower in groupIII (240.4±31.0), than groupI (456.0±35.5) and groupII (438.7±35.0). Additional meperidine was necessary for two patients both in groupsI and II, although none of the patients needed in groupIII. Higher patient satisfaction scores were obtained in group III. Adverse effect incidences were higher in groupI and II than in groupIII. As a result, we believe that to improve analgesic quality after open cholecystectomy, preoperative single dose of gabapentin should at least be 1200 mg.

BibTex	`@article{ agri603, author = {Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen}, title = {Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi}, journal = {Agri}, year = {2007}, volume = {19}, number = {3}, pages = {32-38}, publisher = {The Turkish Society of Algology} }`
RIS	`TY - JOUR AU - Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen PY - 2007 TI - Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi SP - 32 EP - 38 JO - The Journal of the Turkish Society of Algology J2 - Agri VL - 19 IS - 3 PB - ER -`
EndNote	`%0 Journal Article %A Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen %T Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi %J The Journal of the Turkish Society of Algology %D 2007 %V 19 %N 3 %P 32-38`
APA	Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen (2007). Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi. The Journal of the Turkish Society of Algology, 19(3), 32-38.
MLA	Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen. "Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi" The Journal of the Turkish Society of Algology, vol. 19, no. 3, 2007, pp. 32-38.
Chicago	Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen. "Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi" The Journal of the Turkish Society of Algology 19, no. 3 (2007): 32-38.
AMA	Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen. Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi. Agri. 2007; 19(3): 32-38.
Vancouver	Suna Akın Takmaz, Çetin Kaymak, Başak Şare Pehlivan, Bayazit Dikmen. Açık kolesistektomi cerrahisinde preoperatif tek doz oral 900 ve 1200 mg gabapentinin postoperatif ağrı ve tramadol tüketimi üzerine etkisi. Agri. 2007; 19(3): 32-38.

Effect of preoperative 900 and 1200 mg single oral dose of gabapentin on postoperative pain relief and tramadol consumption in open cholecystectomy surgery

Abstract

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