The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice

H. Özbek; Y. Karataş; F. Aksu; D. Özcengiz; S. Y. İnan; G. Işık

H. Özbek^¹, Y. Karataş^², F. Aksu^³, D. Özcengiz^⁴, S. Y. İnan^⁵, G. Işık^⁶

¹Çukurova Üniversitesi Tıp Fakültesi Algoloji Bilim Dalı, Yard. Doç. Dr.
²Çukurova Üniversitesi Tıp Fakültesi Farmakoloji AD., Yard. Doç. Dr.
³Çukurova Üniversitesi Tıp Fakültesi Farmakoloji AD., Prof. Dr.
⁴Çukurova Üniversitesi Tıp Fakültesi Anesteziyoloji AD., Doç. Dr.
⁵Çukurova Üniversitesi Tıp Fakültesi Farmakoloji AD., Arş. Gör.
⁶Çukurova Üniversitesi Tıp Fakültesi Algoloji Bilim Dalı, Prof. Dr.

Keywords: Morphine, L-arginine, N-nitro-L-arginine, antinociception, nitric oxide

Abstract

The effects of L-arginine, a nitric oxide (NO) precursor and N-nitro-L-arginine (L-NA), a nitric oxide synthase (NOS) inhibitor, on morphine-induced analgesia were determined in the mice using tail-flick test. L-arginine (300 and 500 mg/kg, i.p.) and L-NA (4-16 mg/kg, i.p.) did not elicit any analgesic activity. L-NA, but not L-arginine enhanced antinociception induced by morphine (2.5 and 5 mg/kg, s.c). Naloxone, an opioid antagonist, reversed this effect of L-NA. These results suggest that decreased NO synthesis by NOS inhibitors potentiates peripherally administered morphine analgesia.

BibTex	`@article{ agri64, author = {H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık}, title = {The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice}, journal = {Agri}, year = {2000}, volume = {12}, number = {3}, pages = {19-25}, publisher = {The Turkish Society of Algology} }`
RIS	`TY - JOUR AU - H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık PY - 2000 TI - The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice SP - 19 EP - 25 JO - The Journal of the Turkish Society of Algology J2 - Agri VL - 12 IS - 3 PB - ER -`
EndNote	`%0 Journal Article %A H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık %T The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice %J The Journal of the Turkish Society of Algology %D 2000 %V 12 %N 3 %P 19-25`
APA	H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık (2000). The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice. The Journal of the Turkish Society of Algology, 12(3), 19-25.
MLA	H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık. "The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice" The Journal of the Turkish Society of Algology, vol. 12, no. 3, 2000, pp. 19-25.
Chicago	H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık. "The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice" The Journal of the Turkish Society of Algology 12, no. 3 (2000): 19-25.
AMA	H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık. The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice. Agri. 2000; 12(3): 19-25.
Vancouver	H. Özbek, Y. Karataş, F. Aksu, D. Özcengiz, S. Y. İnan, G. Işık. The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice. Agri. 2000; 12(3): 19-25.

The effects of L-arginine and N-nitro-L-arginine on tail-flick response and morphine analgesia in the mice

Abstract

Cite As