Analgesic Effect of Anatolian Propolis in Mice
Kıvanç Kamburoğlu1, Tuncer Özen2
1Ankara University, Faculty Of Dentistry,Oral Diagnosis And Radiology Department
2Gülhane Military Medical Academy, Dental Science Center,oral Diagnosis And Radiology Department
3Gülhane Military Medical Academy, Dental Science Center,department Of Conservative Treatment
Keywords: Propolis, dental pain, analgesia, toothpaste
Abstract
Objective: The aim of the present study was to assess the analgesic effect of Anatolian Propolis, which is added to toothpastes as a prophylactic component for periodontal diseases.
Methods: Water, ethanol and acetone extracted Anatolian Propolis were prepared. Analgesic effect of the extracts was assessed using the tail-flick test in mice (n=6 per each extract). Comparison among groups were made by using one-way ANOVA, followed by post-hoc Scheffe's test to determine significant differences among the means of the data groups. P<0.05 was accepted as significant difference.
Results: We found that water extracted Anatolian Propolis caused a significant increase, 1.61 fold increase (p<0.001 versus control), of the latency time using tail-flick test in mice. However, acetone extracted and ethanol extracted propolis led no significant effect.
Conclusion: We proved the analgesic effect of water extracted Anatolian Propolis. Thus, propolis used in the composition of toothpastes may be beneficial in terms of its analgesic action in addition to its other favorable effects.