Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve

Mehmet Beyazova; Ertan Öztürk; Murat Zinnuroğlu; İsmail Gökyar; Avni Babacan; Kadir Kaya

doi:10.5505/agri.2011.72792

Mehmet Beyazova^¹, Ertan Öztürk^², Murat Zinnuroğlu^¹, İsmail Gökyar^³, Avni Babacan^⁴, Kadir Kaya^⁴

¹Department Of Physical Medicine And Rehabilitation, Gazi University Faculty Of Medicine, Ankara, Turkey.
²Department Of Anaesthesiology And Reanimation, Gazi University Faculty Of Medicine, Ankara, Turkey, (currently At) American Hospital, Istanbul, Turkey
³Department Of Anaesthesiology And Reanimation, Gazi University Faculty Of Medicine, Ankara, Turkey, (currently At) Bayındır Hospital, Ankara, Turkey
⁴Department Of Anaesthesiology And Reanimation, Gazi University Faculty Of Medicine,ankara, Turkey.

Keywords: Tramadol, opioid, nerve block, peripheral nerve, nerve conduction, sural nerve

Abstract

Objectives: The aim of this study was to investigate whether tramadol had a dose dependent blocking effect on nerve conduction when administered perineurally to the sural nerve of healthy volunteers.
Methods: 24 informed healthy subjects were randomized into four equal groups [Saline (placebo), 0.5% tramadol, 1% tramadol and 1.5% tramadol]. The study was designed to be double-blinded. Sensory nerve action potentials were recorded electroneurographically. Two mililiters of study solution was administered to sural nerve perineurally at the level of ankle by the guidance of a nerve stimulator. A sensory block was assumed to have developed when the amplitude of the averaged sensory nerve action potentials diminished below 80% of the baseline value in the subsequent recordings.
Results: According to electroneurographical recordings, none of the volunteers in saline group had block. However, the block rates with 0.5%, 1% and 1.5% tramadol were 1/6, 4/6 and 6/6 respectively (p<0.05). The maximum decrement in the sensory action potential amplitudes with respect to baseline amplitudes given as median values were as follows: 7.8% with saline; 12.5% with 0.5% tramadol; 38.5% with 1% tramadol and 77.5% with 1.5% tramadol (p<0.05). While the median duration of sensory block with 0.5% tramadol was 5 minutes, it was 15 minutes with 1% tramadol and 35 minutes with 1.5% tramadol.
Conclusion: Perineurally administered tramadol blocks sensory nerve conduction of sural nerve in a dose dependent manner.

BibTex	`@article{ agri740, doi = {10.5505/agri.2011.72792}, author = {Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya}, title = {Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve}, journal = {Agri}, year = {2011}, volume = {23}, number = {2}, pages = {51-56}, publisher = {The Turkish Society of Algology} }`
RIS	`TY - JOUR AU - Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya PY - 2011 TI - Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve SP - 51 EP - 56 JO - The Journal of the Turkish Society of Algology J2 - Agri VL - 23 IS - 2 PB - DO - 10.5505/agri.2011.72792 ER -`
EndNote	`%0 Journal Article %A Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya %T Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve %J The Journal of the Turkish Society of Algology %D 2011 %V 23 %N 2 %P 51-56 %R 10.5505/agri.2011.72792`
APA	Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya (2011). Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve. The Journal of the Turkish Society of Algology, 23(2), 51-56. doi:10.5505/agri.2011.72792
MLA	Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya. "Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve" The Journal of the Turkish Society of Algology, vol. 23, no. 2, 2011, pp. 51-56. doi:10.5505/agri.2011.72792.
Chicago	Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya. "Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve" The Journal of the Turkish Society of Algology 23, no. 2 (2011): 51-56. https://doi.org/10.5505/agri.2011.72792.
AMA	Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya. Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve. Agri. 2011; 23(2): 51-56. doi:10.5505/agri.2011.72792.
Vancouver	Mehmet Beyazova, Ertan Öztürk, Murat Zinnuroğlu, İsmail Gökyar, Avni Babacan, Kadir Kaya. Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve. Agri. 2011; 23(2): 51-56. doi:10.5505/agri.2011.72792

Effects of Perineural Tramadol on Nerve Conduction of Sural Nerve

Abstract

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